N-(2-Chloroethyl)dibenzylamine Hydrochloride
Dibenamine Hydrochloride
CAS: 55-43-6
Molecular Formula: C16H19Cl2N
N-(2-Chloroethyl)dibenzylamine Hydrochloride - Names and Identifiers
N-(2-Chloroethyl)dibenzylamine Hydrochloride - Physico-chemical Properties
| Molecular Formula | C16H19Cl2N |
| Molar Mass | 296.23 |
| Density | 1.1507 (rough estimate) |
| Melting Point | 190-193°C(lit.) |
| Boling Point | 449.72°C (rough estimate) |
| Appearance | Crystalline Powder |
| Color | White to off-white |
| Merck | 14,2138 |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.6300 (estimate) |
| MDL | MFCD00012518 |
| In vitro study | Dibenamine (100 nM-10 μM) attenuates the degree of cocaine-induced increase in sensitivity to acetylcholine without any effect on acetylcholine-contraction in isolated vas deferens of guinea pig. Additionally, the degree of dibenamine-induced inhibition dependent on the concentration of dibenamine and inversely related to the concentration of cocaine. |
| In vivo study | Dibenamine hydrochloride (subcutaneousinjection; 25 mg/kg; 48 and 24 hr before the administration of CCl4) decreases the CHCl3, levels at 2 and 6 hr by 30-50 percent, but did not appreciably affect the half-life of CHCl3, in the liver.Pretreatment with Dibenamine apparently slows the conversion of Ccl4 to CHCL3. |
N-(2-Chloroethyl)dibenzylamine Hydrochloride - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | HQ6825000 |
| HS Code | 29214900 |
| Hazard Class | IRRITANT |
| Toxicity | LD50 s.c. in mice: 800 mg/kg (Nickerson, Nomaguchi) |
N-(2-Chloroethyl)dibenzylamine Hydrochloride - Reference Information
| biological activity | Dibenamine hydrochloride is a competitive and irreversible adrenergic (B> adrenergic) blocker that can modify the pharmacological effects of epinephrine. The damage rate of Dibenamine hydrochloride to epinephrine in mice was significantly increased. |
| target | IC50: Adrenergic receptor |
| in vitro study | Dibenamine (100 nM-10 μM) attenuates the degree of cocaine-induced increase in sensitivity to acetylcholine without any effect on acetylcholine-contraction in isolated vas deferens of guinea pig. Additionally, the degree of dibenamine-induced inhibition dependent on the concentration of dibenamine and inversely related to the concentration of cocaine. |
| in vivo study | Dibenamine hydrochloride (subcutaneousinjection; 25 mg/kg; 48 and 24 hr before the administration of CCl4) decreases the CHCl3, levels at 2 and 6 hr by 30-50 percent, but did not appreciably effect the half-life of CHCl3, in the liver.Pretreatment with Dibenamine apparently the conversion of Ccl4 to CHCL3. |
| EPA chemical information | information provided by: ofmpub.epa.gov (external link) |
Last Update：2024-04-09 21:01:54
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